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Abstract #0446

Assessing metabolism and function of normothermically perfused ex vivo livers by multi-nuclear MR imaging and spectroscopy

Liam AJ Young1, Carlo DL Ceresa2, Jack Miller3, Ladislav Valkovic1,4, Daniel Voyce5, Elizabeth M Tunnicliffe1, Jane Ellis1, Damian J Tyler3, Peter J Friend2, Constantin C Coussios6, and Christopher T Rodgers1,7

1Oxford Centre for Clinical Magnetic Resonance Research (OCMR), University of Oxford, Oxford, United Kingdom, 2Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, 3Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom, 4Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, 5OrganOx Ltd, Oxford, United Kingdom, 6Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, 7Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom

Liver transplantation is the only cure for end-stage liver disease. Unfortunately, 20% of patients die waiting for a donor. New techniques for preserving transplant livers, such as normothermic machine perfusion (NMP), provide an opportunity to utilise ‘marginal’ (currently discarded) donated livers if their viability can be assessed accurately. We present initial results from a CE-marked NMP system that we adapted for use in an MRI scanner. We demonstrate the power of NMP-MRI to assess structure and metabolism in a freshly donated pig liver, dynamically over a 10-hour period. Our protocol includes 1H imaging, 31P spectroscopy, and hyperpolarised 13C spectroscopy.

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