Abstract #0448

Oxidative stress measured by in-vivo, longitudinal 1H MRS and ex-vivo ESR spectroscopy in a rat model of chronic Hepatic Encephalopathy

Katarzyna Pierzchala¹, Veronika Rackayova¹, Olivier Braissant², Dario Sessa³, Stefanita Mitrea¹, Andrzej Sienkiewicz⁴, Valérie A. McLin³, Rolf Gruetter¹, and Cristina Cudalbu¹

¹Center for Biomedical Imaging, EPFL, Lausanne, Switzerland, ²Service of Biomedicine, CHUV, Lausanne, Switzerland, ³Swiss Center for Liver Disease in Children, Department of Pediatrics, HUG, Geneva, Switzerland, ⁴Laboratory of Physics of Complex Matter, EPFL, Lausanne, Switzerland

Oxidative stress is believed to play a role in the pathogenesis of chronic hepatic encephalopathy (CHE), however no in-vivo studies to assess the course of cerebral oxidative stress in CHE were performed. We investigated the oxidative stress in the hippocampus of a rat model of chronic HE using in-vivo and longitudinal 1H-MRS combined with ex-vivo ESR spectroscopy. Early changes in brain antioxidants (Asc, 4weeks post-BDL), concomitant with Gln and NH4+ changes were detected for the first time in-vivo. These results were confirmed by ESR spectroscopy suggesting that central oxidative stress is an early event in CHE.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.