Meeting Banner
Abstract #0470

Probing microstructural heterogeneity and mild traumatic brain injury-induced gray matter alterations in the rat brain using diffusion kurtosis imaging

Manisha Aggarwal1, Isabel San Martin2, and Alejandra Sierra2

1Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2University of Eastern Finland, Kuopio, Finland

In heterogeneous brain tissue microenvironments, the probability distribution of spin displacements deviates from Gaussianity. Examining the non-Gaussian behavior of the diffusion-encoded signal with diffusion kurtosis imaging (DKI) could potentially allow probing cellular heterogeneity and injury-induced changes that are not discernible in the limited (q,t)-regime that pulsed-gradient DTI with conventional b-values explores. Here, we investigated the sensitivity of DKI to intrinsic cellular heterogeneity and mild traumatic brain injury (mTBI)-induced gray matter (GM) alterations in the rat brain. The results demonstrate distinct contrasts in mean kurtosis maps reflecting microstructural heterogeneity in GM regions, and detection of region-specific alterations in the cortex and thalamus.

This abstract and the presentation materials are available to members only; a login is required.

Join Here