Abstract #0471

Cross-vendor and Cross-protocol harmonisation of diffusion MRI data: a comparative study

Chantal MW Tax¹, Francesco Grussu^2,3, Enrico Kaden³, Lipeng Ning⁴, Umesh Rudrapatna¹, John Evans¹, Samuel St-Jean⁵, Alexander Leemans⁵, Santi Puch⁶, Matt Rowe⁶, Paulo Rodrigues⁶, Vesna Prčkovska⁶, Simon Koppers^7,8, Dorit Merhof⁸, Aurobrata Ghosh³, Ryutaro Tanno^3,9, Daniel C Alexander³, Cyril Charron¹, Slawomir Kusmia¹, David EJ Linden¹, Derek K Jones¹, and Jelle Veraart¹⁰

¹CUBRIC, School of Psychology, Cardiff University, Cardiff, United Kingdom, ²Queen Square MS Centre, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, ³Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom, ⁴Harvard Medical School, Boston, MA, United States, ⁵Image Sciences Institute, Department of Radiology, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands, ⁶Mint Labs Inc, Barcelona, Spain, ⁷Department of Radiology, University of Pennsylvania and the Children's Hospital of Philadelphia, Philadelphia, PA, United States, ⁸Institute of Imaging & Computer Vision, RWTH Aachen University, Aachen, Germany, ⁹Machine Intelligence and Perception group, Microsoft Research Cambridge, Cambridge, United Kingdom, ¹⁰New York University, New York, NY, United States

We present a comparison of five different methods that estimate mappings between scanners for diffusion MRI data harmonisation. The methods are evaluated on a dedicated dataset of the same subjects acquired on three distinct scanners with ‘standard’ and ‘state-of-the-art’ protocols, with the latter having higher spatial and angular resolution. Our results show that cross-vendor harmonisation and spatial/angular resolution enhancement of single-shell diffusion data sets can be performed reliably, although some challenges remain. The dataset is available upon request and can serve as a useful testbed for future method development in cross-site/cross-hardware and cross-vendor diffusion MRI harmonisation.

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