A novel segmentation method using the direction-averaged DWI signal is proposed. Two images can be obtained from the fitting of the direction-averaged DWI signal: one with superior contrast between the gray matter and white matter; one with prominent CSF contrast. A pseudo T1 weighted image can be constructed and standard segmentation tools can be applied. The method was tested on the HCP subjects in SPM12 and FSL, and showed good agreement with segmentation using the T1 weighted image with the same resolution.
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