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Abstract #0480

Estimation of a signal-appropriate reference volume to improve registration of high b-value diffusion volumes in the human placenta

Conrad P Rockel1, Barbra de Vrijer2,3, and Charles McKenzie1,3

1Medical Biophysics, Western University, London, ON, Canada, 2Dept of Obstetrics and Gynaecology, Western University, Ontario, ON, Canada, 3Division of Maternal, Fetal, and Newborn Health, Children's Health Research Institute, London, ON, Canada

A technique is presented to aid in better motion correction of high b-value diffusion images of the human placenta in utero for the purposes of quantification using intra-voxel incoherent motion (IVIM). A registration reference volume is calculated with signal intensities and tissue features with similarity to volumes with high diffusion weighting, and produce more successful registrations than when using the b=0 volume as a reference.

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