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Abstract #0487

Vascular risk factors and intracranial atherosclerosis at 7T vessel wall MRI in Caucasian ischemic stroke and TIA patients

Arjen Lindenholz1, Anja G. van der Kolk1, Irene C. van der Schaaf1, Bart H. van der Worp2, Anita A. Harteveld1, Nikki Dieleman1, Michiel L. Bots3, and Jeroen Hendrikse1

1Radiology, UMC Utrecht, Utrecht, Netherlands, 2Neurology, UMC Utrecht, Utrecht, Netherlands, 3Epidemiology, UMC Utrecht, Utrecht, Netherlands

There is a lack of knowledge on the association between cardiovascular risk factors and intracranial atherosclerotic lesion burden in the Caucasian population. In this study 105 Caucasian stroke and TIA patients underwent 7T intracranial vessel wall imaging within 3 months after symptom onset. Poisson regression analysis showed that older age, higher systolic blood pressure, diabetes mellitus and a higher SMART risk score (wherein multiple cardiovascular risk factors are combined) were associated with a higher number of vessel wall lesions. Controversially, dyslipidemia and cigarette smoking were not associated with the severity of intracranial vessel wall lesions.

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