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Abstract #0486

Increases in the Prevalence of Subclinical Cerebrovascular Atherosclerosis with Age: A 3.0 T Magnetic Resonance Imaging Study of Community-based Adults

Xihai Zhao1, Gaifen Liu2, Runhua Zhang2, Xiaoyi Chen3, Dongye Li3, Yong Jiang2, Yilong Wang2, Yongjun Wang2, and Chun Yuan1,4

1Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, China, 2Department of Neurology, Beijing Tiantan Hospital, Beijing, China, 3Center for Brain Disorders Research, Capital Medical University and Beijing Institute for Brain Disorders, Beijing, China, 4Department of Radiology, University of Washington, Seattle, WA, United States

It is well established that atherosclerotic diseases occurring in intracranial and extracranial carotid arteries are associated with ischemic cerebrovascular events. It is important to find a surrogate risk factor for subclinical cerebrovascular atherosclerosis in asymptomatic subjects for stroke prevention. This study sought to investigate the association between age and subclinical cerebrovascular atherosclerosis in community-based adults using MR vessel wall imaging. We found that the prevalence of cerebrovascular atherosclerotic plaques increased with age. The association between age and cerebrovascular atherosclerosis suggests that age was an independent indicator for subclinical cerebrovascular atherosclerosis.

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