Abstract #0490

Association between Vulnerability of Carotid Artery Atherosclerotic Plaques and White Matter Lesions in Asymptomatic Elderly Population: A MR Vessel Wall Imaging Study

Ying Cai¹, Yang Liu², Qiang Zhang³, Weizhong Tian¹, Chun Yuan^3,4, Cheng Li⁵, Wei Wang², and Xihai Zhao³

¹Department of Radiology, Taizhou People's Hospital, Taizhou, China, ²Department of Radiology, Yangzhou First People’s Hospital, Yangzhou, China, ³Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, ⁴Department of Radiology, University of Washington, Seattle, WA, United States, ⁵Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China

This study investigated the relationship between morphological and compositional characteristics of carotid artery atherosclerotic plaques and WML in asymptomatic elderly population using 3D multicontrast MR vessel wall imaging. We found that carotid artery plaque compositional characteristics, especially calcification, intraplaque hemorrhage, and high risk plaque, were significantly associated with the severity of WML, suggesting that vulnerable atherosclerotic plaque in carotid artery might be an independent indicator for cerebral ischemic lesions in asymptomatic elderly adults.

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