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Abstract #0490

Association between Vulnerability of Carotid Artery Atherosclerotic Plaques and White Matter Lesions in Asymptomatic Elderly Population: A MR Vessel Wall Imaging Study

Ying Cai1, Yang Liu2, Qiang Zhang3, Weizhong Tian1, Chun Yuan3,4, Cheng Li5, Wei Wang2, and Xihai Zhao3

1Department of Radiology, Taizhou People's Hospital, Taizhou, China, 2Department of Radiology, Yangzhou First People’s Hospital, Yangzhou, China, 3Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, 4Department of Radiology, University of Washington, Seattle, WA, United States, 5Department of Radiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, China

This study investigated the relationship between morphological and compositional characteristics of carotid artery atherosclerotic plaques and WML in asymptomatic elderly population using 3D multicontrast MR vessel wall imaging. We found that carotid artery plaque compositional characteristics, especially calcification, intraplaque hemorrhage, and high risk plaque, were significantly associated with the severity of WML, suggesting that vulnerable atherosclerotic plaque in carotid artery might be an independent indicator for cerebral ischemic lesions in asymptomatic elderly adults.

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