Abstract #0491

Intraplaque Hemorrhage and Calcification Detection with Quantitative Susceptibility Mapping

Chaoyue Wang¹, Saifeng Liu², Yongsheng Chen², Sagar Buch³, Zhaoyang Fan⁴, E. Mark Haacke², and Qi Yang⁵

¹Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom, ²The MRI Institute for Biomedical Research, Detroit, MI, United States, ³Center for Functional and Metabolic Mapping, Robarts' research institute, Western University, London, ON, Canada, ⁴Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁵Xuanwu Hospital, Capital Medical University, Beijing, China

In carotid atherosclerosis, the vulnerable feature that has drawn the most attention is intraplaque hemorrhage (IPH). Clinically, MPRAGE has been used to detect IPH. However, IPH has several drawbacks. The susceptibility difference between arterial blood, vessel wall and different types of plaque makes QSM a potential tool for carotid plaque imaging. The purpose of this work was to develop an optimized protocol for both intraplaque hemorrhage and calcification imaging using Quantitative Susceptibility Mapping (QSM) and demonstrate initial clinical validation of QSM as a tool for characterizing components of carotid plaque.

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