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Abstract #0493

Flow Compensation in Dynamic Susceptibility Contrast MRI for an Increase in Arterial Input Function Precision

Benoît Bourassa-Moreau1, Réjean Lebel1, Guillaume Gilbert2, David Mathieu3, and Martin Lepage1

1Centre d’imagerie moléculaire de Sherbrooke, Département de médecine nucléaire, Université de Sherbrooke, Sherbrooke, QC, Canada, 2MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada, 3Service de neurochirurgie, Département de chirurgie, Université de Sherbrooke, Sherbrooke, QC, Canada

Arterial input functions (AIF) measured inside major arteries in perfusion MRI are derived from the contrast agent induced changes in the blood signal. Such signal measurements of flowing blood are prone to (in)flow induced effects. Here, the effects of pulsatile blood flow are studied for AIF measurement in dynamic susceptibility contrast (DSC) with dual-echo single-shot EPI. First moment flow compensation is shown to partially recover the noise attributed to flow effects. The resulting signal-to-noise ratio is increased by a factor of 14 (2) in the middle (internal) carotid artery providing a more precise AIF for cerebral blood flow calculation.

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