Abstract #0494

Comparison of Cerebral Blood Volume Estimates using Quantitative Susceptibility Mapping, and R2* relaxometry

Leonardo A Rivera-Rivera¹, Ante Zhu¹, Timothy Colgan ², Diego Hernando^1,2, Tilman Schubert³, Patrick A Turski^1,2, and Kevin M Johnson^1,2

¹Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, ³Department of Radiology, Basel University Hospital, Basel, Switzerland

Intracranial vascularity is modified in a wide array of diseases, including various forms of dementia, cancer, and stroke. When assessment of the vascular architecture is needed, one potential approach is steady state imaging with ferumoxytol to estimate cerebral blood volume (CBV). Building upon recent work, in this study we investigate the correlation between QSM and R2* based CBV estimates. Results from 19 healthy volunteers show that the QSM based CBV estimates demonstrated a high degree of correlation in gray and white matter, but larger variance than R2* based measures.

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