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Abstract #0496

Accelerated dynamic quantitative perfusion imaging using an optimized simultaneous multi-slice (SMS) spin and gradient echo (SAGE) sequence with joint-virtual coil (JVC) reconstruction

Mary Kate Manhard1, Berkin Bilgic1, Congyu Liao1,2, SoHyun Han1, Thomas Witzel1, Yi-Fen Yen1, and Kawin Setsompop1

1MGH Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, United States, 2Department of Biomedical Engineering, Zhejiang University, Hangzhou, China

A 5-echo spin and gradient echo (SAGE) sequence was implemented with SMS to provide whole brain coverage at a high spatio-temporal resolution during DSC imaging. Complementary k-space sampling between echoes and joint-virtual coil (JVC) reconstruction were used to achieve high quality reconstruction at 9x acceleration, which enabled 1.9x1.9x5 mm whole-brain imaging at a TR of 1.6s. The multi-echo images from this sequence were fit to achieve quantitative R2 and R2* maps for each TR. This has been shown to limit T1 leakage effects and provide more accurate and detailed perfusion measures with the potential to better assess tumor diagnostics and progression.

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