Abstract #0497

Quantitative assessment of exercise-stimulated muscle perfusion: a comparison between DCE and DSC imaging

Jeff L Zhang¹, Christopher C Conlin¹, Stephen Decker², Gwenael Layec², Jiawei Dong¹, Xiaowan Li¹, Nan Hu³, Christopher Hanrahan¹, Lillian Khor⁴, Michelle Mueller⁵, and Vivian S Lee¹

¹Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States, ²Division of Geriatrics, University of Utah, Salt Lake City, UT, United States, ³Epidemiology, University of Utah, Salt Lake City, UT, United States, ⁴Cardiovascular Medicine, University of Utah, Salt Lake City, UT, United States, ⁵Vascular Surgery, University of Utah, Salt Lake City, UT, United States

For one group of healthy subjects, we measured exercise-stimulated perfusion in calf muscles using both DCE and DSC MRI, and found that the muscle perfusion estimates by the two methods were comparable, but the vascular-fraction estimates were not. Without confounding contribution from extravascular signals, DSC data has the potential of characterizing tissue vasculature more precisely. Acquisition of both DCE and DSC data in one exam can be achieved with either two injections of low contrast dose or acquisition techniques of interleaved T₁ and T₂* imaging.

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