Abstract #0503

Multi-parametric MRI data fusion reveals acute and persistent brain changes in concussed female varsity rugby players

Kathryn Y. Manning^1,2, Alberto Llera³, Robert Bartha^1,2, Gregory A. Dekaban^4,5, Christy Barreira⁴, Arthur Brown ^4,6, Lisa Fischer⁷, Tatiana Jevreomvic⁷, Kevin Blackney⁴, Timothy J. Doherty⁸, Douglas D. Fraser⁹, Jeff Holmes¹⁰, Christian F. Beckmann^3,11,12, and Ravi S. Menon^1,2

¹Medical Biophysics, Western University, London, ON, Canada, ²Centre for Functional and Metabolic Mapping, Robarts Research Institute, London, ON, Canada, ³Donders Centre for Cognitive Neuroimaging, Radboud University, Nijmegen, Netherlands, ⁴Molecular Medicine, Robarts Research Institute, London, ON, Canada, ⁵Microbiology and Immunology, Western University, London, ON, Canada, ⁶Anatomy and Cell Biology, Western University, London, ON, Canada, ⁷Primary Care Sport Medicine, Fowler Kennedy Sport Medicine, London, ON, Canada, ⁸Physical Medicine and Rehabilitation, Western University, London, ON, Canada, ⁹Paediatrics Critical Care Medicine, London Health Sciences Centre, London, ON, Canada, ¹⁰Occupational Therapy, Western University, London, ON, Canada, ¹¹Cognitive Neuroscience, Radboud University Medical Centre, Nijmegen, Netherlands, ¹²Centre for Functional MRI of the Brain (FMRIB), Oxford University, Oxford, United Kingdom

Multi-parametric 3T MRI data was acquired in female varsity rugby players during the in- and off-season and compared to concussed teammates acutely (24-72 hours) and longitudinally (3- and 6-months) after a mild traumatic brain injury (mTBI). Using linked independent component analysis, we found acute and prolonged resting state functional connectivity and diffusion white matter microstructure changes that persisted beyond symptomatic recovery and clearance to return to play. These fused components also significantly correlated with aspects of concussion history and were robust and consistent across model orders and within individual concussed athletes longitudinally.

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