Abstract #0504

Chronic Neurovascular Dysfunction in a Mouse Model of Repeated Mild Traumatic Brain Injury

Conner Robert Adams¹, Paolo Bazzigaluppi², Tina L Beckett², Jossana Bishay², Joe Steinman^1,3, Lydiane Hirschler^4,5,6, Jan M Warnking^4,6, Emmanuel L Barbier^4,6, JoAnne McLaurin^2,7, John G Sled^1,3, and Bojana Stefanovic^1,2

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Sunnybrook Research Institute, Toronto, ON, Canada, ³Mouse Imaging Centre, Toronto, ON, Canada, ⁴Grenoble Institut des Neurosciences, Université Grenoble Alpes, Grenoble, France, ⁵Bruker Biospin MRI, Ettlingen, Germany, ⁶Inserm, U1216, Grenoble, France, ⁷Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

In-situ assessments of brain function following repeated mild traumatic brain injury (rmTBI) have yet to be seen. Herein, we report the first functional imaging study in the chronic phase of a mouse model of rmTBI. Pseudo-continuous arterial spin labelling MRI revealed a reduction in basal cerebral blood flow and cerebral reactivity, while electrophysiological recordings of evoked responses were greatly reduced in injured brain. Finally, immunohistochemical analysis of vascular endothelium, astrogliosis, and neurons was performed to investigate cellular populations.

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