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Abstract #0506

Ribbon Tractography Reveals Reorientation of White Matter in the Corpus Callosum Following Severe Traumatic Brain Injury

Choukri Mekkaoui1, Brian L Edlow2, William J Kostis3, Marcel P Jackowski4, Kawin Setsompop1, Thomas Witzel1, Qiuyun Fan1, Ned A Ohringer1, Javier Cabrera3, Timothy G Reese1, Ona Wu1, and Susie Y Huang1

1Harvard Medical School - Massachusett General Hospital - Martinos Center for Biomedical Imaging, Boston, MA, United States, 2Department of Neurology, Massachusetts General Hospital, Boston, MA, United States, 3Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, United States, 4University of São Paulo, São Paulo, Brazil

Traditional streamline tractography does not capture the changes in fiber twisting resulting from traumatic brain injury. We used ribbon tractography to quantify the acute directional changes in white matter tracts in patients with traumatic brain injury. We identified significant changes in the corpus callosum of these patients both as compared to healthy controls and between the acute and follow-up scans of a subset of patients. These findings reveal alterations in the architecture of the corpus callosum within and beyond the area of injury and offer a potential marker for structural changes that are not detected by standard techniques.

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