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Abstract #0507

The Evolution of White Matter Microstructural Changes after Mild Traumatic Brain Injury: A Longitudinal DTI and NODDI Study

Eva M Palacios1, Julia P Owen2, Esther L Yuh1,3, Mary Vassar3,4, Geoffrey T Manley3,4, and Pratik Mukherjee1,3,5

1Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, 2Department of Radiology, University of Washington, Seattle, WA, United States, 3Brain and Spinal Cord Injury Center, San Francisco General Hospital and Trauma Center, San Francisco, CA, United States, 4Department of Neurological Surgery and Brain and Spinal Injury Center, University of California San Francisco, San Francisco, CA, United States, 5Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, United States

Problem: Mild traumatic brain injury (mTBI) can result in long-term sequelae. Lack of sensitive biomarkers makes diagnosis challenging. Methods: Cross-sectional and longitudinal study of 40 mTBI patients at 2 weeks and 6 months after injury. Diffusion tensor imaging and multishell neurite orientation dispersion and density imaging (NODDI) parameters were assessed. Results: Cross-sectional analysis between patients at 2-weeks and controls revealed a decrease of fractional anisotropy and increase of mean diffusivity in the patient group together with elevated free water values. Longitudinally, after mTBI, a decline in neurite density was observed. Conclusions: NODDI measurements are sensitive imaging biomarkers for the subtle underlying white matter pathology after mTBI.

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