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Abstract #0508

5-Year Arterial Spin Labeling MR Perfusion sequelae of concussive blast traumatic brain injury

Swati Rane1, Jalal B Andre1, Jason Barber1, Nancy Temkin1, and Christine MacDonald1

1University of Washington Medical Center, Seattle, WA, United States

Concussive blast traumatic brain injury (cbTBI) may benefit from evaluation with advanced MR imaging techniques. Here we report the results of a 5-year follow-up prospective, observational, longitudinal human cohort study evaluating cbTBI using arterial spin labeling, correlated with durable measures of long term outcome taken from an extensive battery of neurobehavioral, neuropsychological, and psychiatric evaluations. Specifically, service members who sustained combat-related cbTBI exhibited significant, regional hypoperfusion 5 years post-injury compared to combat-deployed controls, associated with measures of long term outcome.

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