Meeting Banner
Abstract #0512

Metabolic concentrations in normal appearing brain tissue: 3 month after severe pediatric TBI.

Petr Menshchikov1,2, Natalia Semenova1,2,3, Andrei Manzhurtsev2,3, Maxim Ublinskii2,3, Ilya Melnikov2, and Tolib Akhadov2

1Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russian Federation, 2Clinical and Research Institute of Emergency Pediatric Surgery and Trauma, Moscow, Russian Federation, 3Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, Russian Federation

In this study for the first time cerebral NAA, Asp and Glu concentrations of major inhibitory were simultaneously estimated in patients severe TBI . This work revealed significant reduction NAA and Asp concentrations in frontal lobe (on 65 and 61% respectively) in patients with severe TBI as compare to control group. At the same time, there was no significant change in Glu concentration. Our findings indicate that the main reason for the [NAA] reduction in the chronic severe TBI is caused by a decrease in [Asp]. Precursor of synthesis [NAA]. [Asp] reduction along with an unchanged Glu level may be caused by the dysfunction of one of the most important metabolic regulation systems - the malate-aspartate shuttle (MAS).

This abstract and the presentation materials are available to members only; a login is required.

Join Here