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Abstract #0513

Noninvasive Staging of Liver Fibrosis using Magnetic Resonance, Ultrasound, and Transient Elastography: a Comparison with Liver Biopsy

Thierry Lefebvre1, André Ilinca1, Claire Wartelle-Bladou2, Giada Sebastiani3, Hélène Castel2, Bich Ngoc Nguyen4,5, Jessica Murphy-Lavallée6, Damien Olivié6, Guillaume Gilbert6,7, and An Tang1,6

1Centre de recherche du centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada, 2Department of Gastroentology and Hepatology, Université de Montréal, Montreal, QC, Canada, 3Department of Medicine, Division of Gastroenterology, McGill University Health Centre (MUHC), Montreal, QC, Canada, 4Department of Pathology, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, QC, Canada, 5Department of Pathology and Cellular Biology, Université de Montréal, Montreal, QC, Canada, 6Department of Radiology, Radio-Oncology and Nuclear Medicine, Université de Montréal, Montreal, QC, Canada, 7MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada

Elastographic techniques measure liver stiffness as surrogate biomarker of liver fibrosis. We performed paired comparisons of MRE, pSWE, and TE for staging liver fibrosis. For classification of dichotomized fibrosis stages F0 vs. ≥ F1, ≤ F1 vs. ≥ F2, ≤ F2 vs. ≥ F3, and ≤ F3 vs. F4, the AUCs were respectively 0.92, 0.84, 0.89, 0.89 for MRE; 0.76, 0.83, 0.80, 0.75 for pSWE; and 0.75, 0.70, 0.77, 0.84 for TE. Overall, MRE provided a diagnostic accuracy similar or higher than ultrasound-based elastographic techniques.

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