Abstract #0513

Noninvasive Staging of Liver Fibrosis using Magnetic Resonance, Ultrasound, and Transient Elastography: a Comparison with Liver Biopsy

Thierry Lefebvre¹, André Ilinca¹, Claire Wartelle-Bladou², Giada Sebastiani³, Hélène Castel², Bich Ngoc Nguyen^4,5, Jessica Murphy-Lavallée⁶, Damien Olivié⁶, Guillaume Gilbert^6,7, and An Tang^1,6

¹Centre de recherche du centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada, ²Department of Gastroentology and Hepatology, Université de Montréal, Montreal, QC, Canada, ³Department of Medicine, Division of Gastroenterology, McGill University Health Centre (MUHC), Montreal, QC, Canada, ⁴Department of Pathology, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, QC, Canada, ⁵Department of Pathology and Cellular Biology, Université de Montréal, Montreal, QC, Canada, ⁶Department of Radiology, Radio-Oncology and Nuclear Medicine, Université de Montréal, Montreal, QC, Canada, ⁷MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada

Elastographic techniques measure liver stiffness as surrogate biomarker of liver fibrosis. We performed paired comparisons of MRE, pSWE, and TE for staging liver fibrosis. For classification of dichotomized fibrosis stages F0 vs. ≥ F1, ≤ F1 vs. ≥ F2, ≤ F2 vs. ≥ F3, and ≤ F3 vs. F4, the AUCs were respectively 0.92, 0.84, 0.89, 0.89 for MRE; 0.76, 0.83, 0.80, 0.75 for pSWE; and 0.75, 0.70, 0.77, 0.84 for TE. Overall, MRE provided a diagnostic accuracy similar or higher than ultrasound-based elastographic techniques.

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