Multifrequency MR elastography MRE was applied to detect fibrosis and steatosis, two pathological features associated with pediatric non-alcoholic fatty liver disease (NAFLD). Shear wave speed (c) obtained from MRE is a measure of tissue stiffness and can differentiate moderate from advanced fibrosis. Penetration rate (a) as another MRE parameter is able to detect moderate steatosis and is negatively correlated with hepatic fat fraction. Both MRE derived mechanical parameters c and a are independently responsive to fibrosis and steatosis and could be used in the future as imaging markers for the noninvasive assessment of prediatric NAFLD.
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