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Abstract #0520

Can Negligible Hepatic Steatosis Determined by MRI-Proton Density Fat Fraction Obviate the Need for Liver Biopsy in Potential Liver Donors?

Kartik Jhaveri1, Janakan Satkunasingham1, Hooman Hosseini Nik1, Sandra Fischer1, Ravi Menezes1, Nazia Selzner1, Mark Cattral1, and David Grant1

1UHN, Toronto, ON, Canada

Hepatic steatosis in potential liver donor candidates has important implications towards outcomes of liver transplant recipients and donor safety. Hepatic steatosis in potential donors in excess of established but varying institutional thresholds are considered as grounds for donor ineligibility. However, negiblible/absent hepatic steatosis (<5%) is considered acceptable universally. Currently Liver biopsy is regarded as reference standard. We show in our study that MR-PDFF has very high NPV for excluding significant hepatic steatosis (>10%). Thus MRI-PDFF can be utilized for liver donor screening and obviates the need for liver biopsy when MRI-PDFF values are <5%

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