Meeting Banner
Abstract #0521

Intravoxel Incoherent Motion Diffusion-weighted MRI for Assessing Necroinflammation in Patients with Chronic Liver Disease

Thierry Lefebvre1, Guillaume Gilbert2,3, Claire Wartelle-Bladou4, Giada Sebastiani5, Hélène Castel4, Bich Ngoc Nguyen6,7, Damien Olivié3, and An Tang1,3

1Centre de recherche du centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada, 2MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada, 3Department of Radiology, Radio-Oncology and Nuclear Medicine, Université de Montréal, Montreal, QC, Canada, 4Department of Gastroentology and Hepatology, Université de Montréal, Montreal, QC, Canada, 5Department of Medicine, Division of Gastroenterology, McGill University Health Centre (MUHC), Montreal, QC, Canada, 6Department of Pathology, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, QC, Canada, 7Department of Pathology and Cellular Biology, Université de Montréal, Montreal, QC, Canada

Necroinflammation is a hallmark feature in several causes of chronic liver disease. Because it has multiple tissue contrast mechanisms, MRI is ideally suited for characterization of histopathological changes (i.e. inflammation, fat, iron, and fibrosis) that may occur concomitantly in chronic liver disease. We evaluated intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) MRI for assessment of necroinflammation. Perfusion fractions were significantly correlated with necroinflammation grades (ρ = 0.49, P < 0.0001) and could discriminate grades ≤ A1 vs. ≥ A2 and ≤ A2 vs. A3 with good accuracy (AUC: 0.81 and 0.80, respectively). Our results suggest that perfusion fraction may be used for assessing liver necroinflammation.

This abstract and the presentation materials are available to members only; a login is required.

Join Here