Abstract #0521

Intravoxel Incoherent Motion Diffusion-weighted MRI for Assessing Necroinflammation in Patients with Chronic Liver Disease

Thierry Lefebvre¹, Guillaume Gilbert^2,3, Claire Wartelle-Bladou⁴, Giada Sebastiani⁵, Hélène Castel⁴, Bich Ngoc Nguyen^6,7, Damien Olivié³, and An Tang^1,3

¹Centre de recherche du centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada, ²MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada, ³Department of Radiology, Radio-Oncology and Nuclear Medicine, Université de Montréal, Montreal, QC, Canada, ⁴Department of Gastroentology and Hepatology, Université de Montréal, Montreal, QC, Canada, ⁵Department of Medicine, Division of Gastroenterology, McGill University Health Centre (MUHC), Montreal, QC, Canada, ⁶Department of Pathology, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, QC, Canada, ⁷Department of Pathology and Cellular Biology, Université de Montréal, Montreal, QC, Canada

Necroinflammation is a hallmark feature in several causes of chronic liver disease. Because it has multiple tissue contrast mechanisms, MRI is ideally suited for characterization of histopathological changes (i.e. inflammation, fat, iron, and fibrosis) that may occur concomitantly in chronic liver disease. We evaluated intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) MRI for assessment of necroinflammation. Perfusion fractions were significantly correlated with necroinflammation grades (ρ = 0.49, P < 0.0001) and could discriminate grades ≤ A1 vs. ≥ A2 and ≤ A2 vs. A3 with good accuracy (AUC: 0.81 and 0.80, respectively). Our results suggest that perfusion fraction may be used for assessing liver necroinflammation.

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