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Abstract #0524

Developmental Score of the Neonatal Brains: Characterizing Diffusion MRI Changes in the Term- and Preterm-born Infants

Dan Wu1, Linda Chang2, Thomas Ernst2, Jon Skranes3, and Kenichi Oishi1

1Radiology, Johns Hopkins University School of Medicine, BALTIMORE, MD, United States, 2Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, BALTIMORE, MD, United States, 3Laboratory Medicine, Children’s and Women’s Health, Norwegian University of Science and Technology, Trondheim, Norway

Postmenstrual age (PMA) is used as a time-scale to evaluate brain development, but it contains inaccuracy with regards to the estimated time of conception because the duration from the last menstrual period to conception varies. To address this variation, we designed a developmental score (DevS) that aligned individuals with similar development patterns together, and provides a linear trajectory of DTI-measurement as a function of an underlying brain developmental index. Compared to PMA, DevS showed an improved the regression with DTI-measurements, and it better separated the developmental differences between term- and preterm-born infants.

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