Abstract #0525

Quantitative assessment of pediatric brain myelination in a clinical setting using macromolecular proton fraction

Vasily L. Yarnykh^1,2, Nina V. Knipenberg ³, and Olga L. Tereshchenkova³

¹Radiology, University of Washington, Seattle, WA, United States, ²Research Institute of Biology and Biophysics, Tomsk State University, Tomsk, Russian Federation, ³Radiology, First Children's Hospital, Tomsk, Russian Federation

The fast macromolecular proton fraction (MPF) mapping method has been implemented as a part of a clinical pediatric MRI protocol for a 1.5T MRI scanner. 3D MPF maps were obtained from 31 pediatric patients aged from 2 weeks to 7 years without abnormal brain findings. MPF maps allowed robust quantitation of age-related changes in the myelin content. Temporal trajectories of regional brain myelination were analyzed using the general logistic model that enabled the formal description of distinctions in the onset and speed of myelination across a range of white and gray matter structures.

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