Abstract #0526

MR Fingerprinting enables quantitative measures of brain tissue relaxation times and myelin water fraction in early brain development

Yong Chen¹, Meng-Hsiang Chen², Weili Lin¹, and UNC/UMN Baby Connectome Project Consortium¹

¹Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ²Chang Gung University College of Medicine, Kaohsiung, Taiwan

In this study, a high-resolution MR Fingerprinting technique was developed for rapid and simultaneous quantification of T1, T2 and myelin water fraction in pediatric neuroimaging. The method was applied to five subjects from 3 months to 52 months old and high quality quantitative maps were obtained from all subjects without evident motion artifacts. Our preliminary results also show a trend of decrease in T1/T2 and increase of myelin water fraction with age, which are consistent with finding in literature.

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