Abstract #0527

Patterns of subcortical gray matter and white matter myelination from 4.5 months to 1 year-old: an observational study comparing the whole brain T1w/T2w ratio myelin mapping technique and an autopsy infant myelin-staining study

Joseph Yuan-Mou Yang^1,2,3, Jian Chen¹, Michelle Hao Wu⁴, Simone Mandelstam^4,5,6,7, Richard Leventer^2,8, Bonnie Yuan-Mou Alexander^1,9, Deanne Thompson^1,9, Marc Seal^1,5, and Richard Beare^1,10

¹Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia, ²Neuroscience Research, Murdoch Children's Research Institute, Melbourne, Australia, ³Neurosurgery, The Royal Children's Hospital, Melbourne, Australia, ⁴Medical Imaging, The Royal Children's Hospital, Melbourne, Australia, ⁵Paediatrics, University of Melbourne, Melbourne, Australia, ⁶Radiology, University of Melbourne, Melbourne, Australia, ⁷Epilepsy, Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, ⁸Neurology, The Royal Children's Hospital, Melbourne, Australia, ⁹Victorian Infant Brain Study (VIBeS), Murdoch Children's Research Institute, Melbourne, Australia, ¹⁰Medicine, Monash University, Melbourne, Australia

The whole brain T1w/T2w ratio technique enables in vivo quantitative myelin mapping using clinically acquired MRI sequences, which is potentially useful when investigating developmental myelination trajectories. Post-mortem infant myelin-staining studies provide useful references. This study characterizes myelination trajectories of 27 subcortical brain regions in typically developing 4.5 months to 1 year-old children using the T1w/T2w ratio technique and compared the patterns with those demonstrated by an autopsy infant myelin-staining study. Similar myelination trajectory patterns were observed in the structures that commenced myelination before birth. This highlights the T1w/T2w ratio as potential myelin imaging biomarker for these structures during this period.

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