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Abstract #0538

“In vivo” Field-Cycling relaxometry of tumours. Evidence for the role of the intracellular water lifetime as tumour biomarker.

Simonetta Geninatti Crich1, Simona Baroni2, Maria Rosaria Ruggiero1, Stefania Pezzana1, Gianni Ferrante3, and Silvio Aime1

1University of Torino, Torino, Italy, 2University of torino, Torino, Italy, 3Stelar srl, Mede (PV), Italy

This work aims at developing an innovative diagnostic strategy, based on the "in vivo" measurements of longitudinal relaxation times at low and ultra-low magnetic fields with Fast Field Cycling FFC-NMR to obtain quantitative information on tumour metastatic potential, due to different water content and mobility, that is invisible to standard MRI. Preliminary results show that the endogenous contrast between normal and diseased tissue, due to differences in T1, is much greater at low field and the shape of the relaxation dispersion profiles may be used as a reporter of the molecular dynamical processes, biomarkers of the disease grade.

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