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Abstract #0539

In-vivo Vagus Nerve to Central Nervous System Tracing using Manganese Enhanced Magnetic Resonance Imaging

Steven Oleson1, Kun-Han Lu2, Jiayue Cao1, and Zhongming Liu1

1Biomedical Engineering, Purdue University, West Lafayette, IN, United States, 2Electrical and Computer Engineering, Purdue University, West Lafayette, IN, United States

Tracing neuronal connections of the peripheral and central nervous system has relied on invasive techniques that make it difficult to reconstruct information. We demonstrate the feasibility of utilizing manganese enhanced magnetic resonance imaging (MEMRI) and vagus nerve stimulation (VNS) to trace the vagus nerve to central nervous system (CNS) connections. This experimental approach shows the non-invasive visualization and quantified increased enhancement of manganese transport from the nodose ganglion to the left nucleus tractus solitaries (NTS).

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