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Abstract #0548

Rethinking vascular artifacts: testing the sensitivity of ASL vascular signal as a biomarker of disease

Zachary Mulhollan1, Henk-Jan Mutsaerts1, Jan Petr1,2, Ronald S Lazar3, Randolph S Marshall4, and Iris Asllani1

1Rochester Institute of Technology, Rochester, NY, United States, 2Helmholtz-Zentrum Dresden-Rossendorf Institut für Radiopharmazeutische Krebsforschung PET-Zentrum, Dresden, Germany, 3The University of Alabama at Birmingham, Birmingham, AL, United States, 4Columbia University Medical Center, New York, NY, United States

Collateral perfusion has a major effect on clinical outcome in carotid steno-occlusive disease. Arterial spin labeling (ASL) may provide a biomarker of collateral perfusion by measuring arterial transit time (ATT) in addition to cerebral blood flow (CBF). However, the concomitant measurement of ATT and CBF is not feasible for clinical applications. As an alternative, ATT can be estimated from single post-labeling delay ASL image using the spatial coefficient of variance (CoV). In this study, we investigate whether the spatial CoV lateralization through collateral perfusion can predict the side of carotid occlusion as a proof-of-principle. In addition to spatial CoV, we also investigated whether temporal variance (tVAR) of the ASL signal could be used as a predictor of occlusion versus stenosis.

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