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Abstract #0549

Exploiting small fluctuations in labeling efficiency in pseudo-continuous arterial spin labeling for combined flow-territory determination and CBF-mapping

Thijs W. van Harten1 and Matthias J.P. van Osch1

1Department of Radiology, Leiden University Medical Center, Leiden, Netherlands

Since the labeling efficiency in pCASL is dependent on velocity and off-resonance effects, one could imagine that small natural occurring fluctuations at the labeling plane would lead to similar fluctuations in the ASL-signal. Such fluctuations at the brain level would be similar for voxels belonging to the same flow territory and might enable detection of flow territories, e.g. by an ICA-type of resting-state ASL analysis that is normally used for identification of neuronal networks. By deliberately manipulating the labeling efficiency, we can report that with small fluctuations in labeling efficiency flow territories can be determined, which diminish in robustness for smaller fluctuations.

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