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Abstract #0550

The Influence of the cardiac cycle on velocity-selective and acceleration-selective Arterial Spin Labeling

Suzanne L. Franklin1,2, Sophie Schmid1, Clemens Bos2, and Matthias J.P. van Osch1

1C.J. Gorter Center for High Field MRI, Leiden University Medical Center, Leiden, Netherlands, 2Imaging Division, University Medical Center Utrecht, Utrecht, Netherlands

In this study we investigated whether velocity-selective arterial spin labeling (VS-ASL) and acceleration-selective spin labeling (Acc-ASL) can be used to measure pulsatility in the microvascular system of the brain, since the amount of generated label will depend on the velocity or acceleration of the spins at the moment the VS-ASL (Acc-ASL) module is applied. Results showed no significant variation in the amount of label when applying these modules at different cardiac phases. However, the generated label did show a pattern which coincides with the flow territories, suggesting a underlying physiological cause.

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