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Abstract #0552

Contrast Enhancement for Early Tumor Detection by Active-Feedback Field Locking and Refocusing

Fang-Chu Lin1, Chao-Hsiung Hsu1, and Yung-Ya Lin1

1Chemistry & Biochemistry, University of California, Los Angeles, Los Angeles, CA, United States

Early detection of high-grade malignancy using novel contrast mechanisms and detection methods significantly increases the treatment options and the patients’ survival rate. For this purpose, the local magnetic-field-gradient variations due to irregular water contents and deoxyhemoglobin concentration in early glioblastoma multiforme (GBM) is sensitively detected by active-feedback electronic devices and nonlinear spin dynamics. The active-feedback phases and strength were tuned to manipulate the underlying spin dynamics and thus optimize the feedback-induced avalanching spin amplification effect. In vivo results from GBM mouse models show that up to 12 times of improved tumor-to-normal-tissue contrasts can be achieved to highlight early GBM.

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