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Abstract #0553

Measurement of artifact-free arterial input functions for T1-weighted dynamic contrast-enhanced MRI: Inter- and intra-patient variability

Leonidas Georgiou1,2, Daniel J Wilson3, Nisha Sharma4, and David L Buckley1

1Department of Biomedical Imaging Science, University of Leeds, Leeds, United Kingdom, 2Department of Medical Physics, German Oncology Centre, Limassol, Cyprus, 3Department of Medical Physics & Engineering, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 4Department of Radiology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

In 2006, Parker et al published a population-average AIF that has subsequently been used by numerous investigators for both simulation and data analysis. Despite its utility, the published AIF suffers from a number of limitations. In this study we tried to address many of these limitations and made measurements in a population of patients with advanced breast cancer, resulting in a total of 74 individual AIFs. We fitted each AIF with a physiological model and assessed inter- and intra-patient variability.

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