Abstract #0556

Characterization of Breast Lesion using T1-perfusion MRI: Semi- Quantitative Vs Quantitative Analysis

Snekha Thakran¹, Anup Singh^1,2, Pradeep Kumar Gupta³, Vedant Kabra³, and Rakesh Kumar Gupta³

¹Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, ²Department of Biomedical Engineering, AIIMS Delhi, New Delhi, India, ³Department of Radiology and Imaging, Fortis Memorial Research Institute, Gurgaon, New Delhi, India

In this study role of hemodynamic parameters (breast-blood-volume and breast blood-flow), obtained using T₁-perfusion MRI data of breast, in the differentiation of benign from malignant breast lesions and classification of malignant lesions into different grades is evaluated. Hemodynamic parameters were also compared with the tracer kinetic parameters and semi-quantitative T₁-perfusion analysis in term of grading. The high sensitivity and specificity of breast-blood-volume in differentiating between benign and malignant as well as in the grading of breast lesions (grade-I, grade-II and grade-III) were observed.

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