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Abstract #0557

Manganese-enhanced MRI: comparison of agents in the rat pancreas

Lucy Elizabeth Kershaw1, David Lilburn1, Maurits Jansen1, Pilar Jimenez-Royo2, Antonella Napolitano Rosen2, Philip Murphy2, Alexandra Morgan2, Rob Janiczek2, Shareen Forbes3,4, and Scott Semple1,4

1Edinburgh Imaging, The University of Edinburgh, Edinburgh, United Kingdom, 2Experimental Medicine Imaging, GlaxoSmithKline, London, United Kingdom, 3Endocrinology Unit, The University of Edinburgh, Edinburgh, United Kingdom, 4BHF/University of Edinburgh Centre for Cardiovascular Sciences, The University of Edinburgh, Edinburgh, United Kingdom

Type 1 diabetes mellitus results in autoiummune destruction of β-cells in the pancreas, which are responsible for insulin production. Paramagnetic Mn2+ ions are taken up by β-cells as a calcium analogue and could be used as an MR contrast agent to monitor β-cell function and therefore treatment or disease progression in these patients. Three manganese-based contrast agents (MnCl2, mangafodipir and Mn gluconate) were used to measure pancreas enhancement after saline and glucose challenge in healthy rats. All agents showed greater enhancement after glucose challenge, with no marked difference between the two agents that have been used clinically.

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