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Abstract #0560

Evaluating Feasibility of Creatine-weighted CEST MRI in Human Brain at 7T using Z-spectral Fitting Approach

Anup Singh1,2, Mohammad Haris3, Ayan Debnath1, Kejia Cai4, Hari Hariharan5, Puneet Bagga5, and Ravinder Reddy5

1Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, 2Biomedical Engineering, AIIMS Delhi, New Delhi, India, 3Sidra Medical and Research Center, DOHA, Qatar, 4Radiology, University of Illinois at Chicago, Chicago, IL, United States, 5Radiology, University of Pennsylvania, Philadelphia, PA, United States

Creatine(Cr)-weighted chemical-exchange-saturation-transfer(CEST) MRI is being developed to detect alteration in Cr concentration during modulation as well as Cr-associated disorders. Cr-weighted CEST contrast show dependence on saturation parameters and overlap from other effects in brain. The conventional asymmetry approach results in a mixed contrast, which is less specific to Cr. By using appropriate saturation parameters, contamination from some of the metabolites/molecules can be reduced; however, it is difficult to suppress the contamination completely as shown by simulation studies. Proposed protocol and improved z-spectral fitting approach can be used for computing Cr-weighted CEST contrast with reduced contamination in human brain at 7T.

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