Abstract #0560

Evaluating Feasibility of Creatine-weighted CEST MRI in Human Brain at 7T using Z-spectral Fitting Approach

Anup Singh^1,2, Mohammad Haris³, Ayan Debnath¹, Kejia Cai⁴, Hari Hariharan⁵, Puneet Bagga⁵, and Ravinder Reddy⁵

¹Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, ²Biomedical Engineering, AIIMS Delhi, New Delhi, India, ³Sidra Medical and Research Center, DOHA, Qatar, ⁴Radiology, University of Illinois at Chicago, Chicago, IL, United States, ⁵Radiology, University of Pennsylvania, Philadelphia, PA, United States

Creatine(Cr)-weighted chemical-exchange-saturation-transfer(CEST) MRI is being developed to detect alteration in Cr concentration during modulation as well as Cr-associated disorders. Cr-weighted CEST contrast show dependence on saturation parameters and overlap from other effects in brain. The conventional asymmetry approach results in a mixed contrast, which is less specific to Cr. By using appropriate saturation parameters, contamination from some of the metabolites/molecules can be reduced; however, it is difficult to suppress the contamination completely as shown by simulation studies. Proposed protocol and improved z-spectral fitting approach can be used for computing Cr-weighted CEST contrast with reduced contamination in human brain at 7T.

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