Abstract #0559

A Novel MR Fingerprinting Approach for Fast Quantitative Chemical Exchange Saturation Transfer MRI Analysis by Subgrouping Proton Exchange Models (CEST-SPEM)

Hye-Young Heo^1,2, Shanshan Jiang¹, Peter C.M. van Zijl^1,2, and Jinyuan Zhou^1,2

¹Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Most current amide proton transfer (APT) imaging protocols, a variant of CEST-MRI, are essentially not quantitative and acquire qualitative APT-weighted images, limiting pH or concentration specificity. Herein, we propose a novel dictionary-free MRF concept to allow APT quantification by subgrouping proton exchange models (CEST-SPEM). The results of numerical phantom studies demonstrate that CEST-SPEM can enable absolute quantification of the APT exchange rate and concentration on 3T clinical scanners. The same model used for in vivo allows fast quantification of exchange rates and apparent concentrations for the combined solute components at the CEST frequency studied.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.