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Abstract #0594

A connectome-wide investigation of the longitudinal effect of real-time fMRI amygdala neurofeedback emotional training on resting-state connectivity in combat veterans with PTSD

Masaya Misaki1, Raquel Phillips1, Vadim Zotev1, Chung-Ki Wong1, Brent E Wurfel1,2, Frank Krueger3, Matthew Feldner4, and Jerzy Bodurka1,5

1Laureate Institute for Brain Research, Tulsa, OK, United States, 2Laureate Psychiatric Clinic and Hospital, Tulsa, OK, United States, 3George Mason University, Fairfax, VA, United States, 4University of Arkansas, Fayetteville, AR, United States, 5University of Oklahoma, Norman, OK, United States

We introduced a longitudinal Multivariate Distance Matrix Regression (LMDMR) analysis for a connectome-wide study of the longitudinal effect on resting-state fMRI functional connectivity (rsfMRI-fc) without a priori seed definition. We applied this analysis to investigate the effect of real-time fMRI amygdala neurofeedback training in combat veterans with PTSD. The analysis revealed a significant interaction between a decrease in hyperarousal symptom and an increase in rsfMRI-fc between the precuneus and the left superior frontal region. This result suggests that enhanced regulation of emotional memory retrieval helped reduce PTSD symptoms.

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