Abstract #0594

A connectome-wide investigation of the longitudinal effect of real-time fMRI amygdala neurofeedback emotional training on resting-state connectivity in combat veterans with PTSD

Masaya Misaki¹, Raquel Phillips¹, Vadim Zotev¹, Chung-Ki Wong¹, Brent E Wurfel^1,2, Frank Krueger³, Matthew Feldner⁴, and Jerzy Bodurka^1,5

¹Laureate Institute for Brain Research, Tulsa, OK, United States, ²Laureate Psychiatric Clinic and Hospital, Tulsa, OK, United States, ³George Mason University, Fairfax, VA, United States, ⁴University of Arkansas, Fayetteville, AR, United States, ⁵University of Oklahoma, Norman, OK, United States

We introduced a longitudinal Multivariate Distance Matrix Regression (LMDMR) analysis for a connectome-wide study of the longitudinal effect on resting-state fMRI functional connectivity (rsfMRI-fc) without a priori seed definition. We applied this analysis to investigate the effect of real-time fMRI amygdala neurofeedback training in combat veterans with PTSD. The analysis revealed a significant interaction between a decrease in hyperarousal symptom and an increase in rsfMRI-fc between the precuneus and the left superior frontal region. This result suggests that enhanced regulation of emotional memory retrieval helped reduce PTSD symptoms.

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