Abstract #0595

Intra-operative acquisition of sensorimotor fMRI during glioma resection: evaluation of feasibility and clinical applicability.

Adam Kenji Yamamoto¹, Joerg Magerkurth², Laura Mancini^1,3, Mark J White^1,4, Samira M Kazan⁵, Anna Miserocchi⁶, Andrew W McEvoy⁶, Ian Appleby⁷, John Thornton^1,3, Cathy J Price⁵, Nikolaus Weiskopf^5,8, and Tarek A Yousry^1,3

¹Neuroradiological Academic Unit, UCL Institute of Neurology, London, United Kingdom, ²Psychology and Language Sciences, Birkbeck-UCL Centre for Neuroimaging, London, United Kingdom, ³Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, ⁴Medical Physics and Biomedical Engineering, University College London Hospital, London, United Kingdom, ⁵Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, United Kingdom, ⁶Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, United Kingdom, ⁷Department of Neuroanaesthesia, National Hospital for Neurology and Neurosurgery, London, United Kingdom, ⁸Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

Intra-operative fMRI has the potential to improve neurosurgical outcomes and we have previously shown that the task-related BOLD signal can be acquired under general anaesthesia. Our next goal was to acquire fMRI intra-operatively with the skull open.

In 12 patients, we performed 24 acquisitions of a passive sensorimotor paradigm during the resection of their brain tumour. The fMRI data were evaluated by neuroradiologists, assessing its applicability for the provision of a clinical report on the location of sensorimotor activation to the neurosurgeon. 17/24 acquisitions were scored as useful.

We conclude that intra-operative fMRI is feasible and produces clinically useful data.

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