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Abstract #0597

Association between Tremor Severity Improvement and Functional Connectivity Changes after Magnetic Resonance Guided Focused Ultrasonic Thalamotomy Treatment in Essential Tremor Patients

Li Jiang1, Jiachen Zhuo1, Dheeraj Gandhi1, Charlene Aldrich2, Howard Eisenberg2, Paul Fishman3, Elias Melhem1, and Rao Gullapalli1

1Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland Baltimore, Baltimore, MD, United States, 2Department of Neurosurgery, University of Maryland Baltimore, Baltimore, MD, United States, 3Department of Neurology, University of Maryland Baltimore, Baltimore, MD, United States

Essential tremor (ET) is the most common movement disorder and often characterized by a slowly progressive involuntary posture and/or kinetic tremor, usually affecting both upper extremities. Ablation of the ventral intermediate nucleus (VIM) of the thalamus with MRgFUS is an effective and FDA-approved treatment for medication refractory ET patients. However, very little is known regarding brain functional changes before and after the treatment and even less about its association with the tremor severity changes after treatment. This study aimed at investigating the longitudinal tremor improvement and its association with the changes of Functional connectivity of left VIM at 1-year post-treatment.

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