Abstract #0604

Real-time MR Brain Infusion Monitoring Enables Accurate Prediction of End Drug Distribution

Martin Brady¹, Raghu Raghavan¹, Peng Wang², Miles Olsen³, Ethan K. Brodsky², Terrence Oakes², Andrew L Alexander^2,4,5, and Walter F. Block^2,4,6,7

¹Therataxis, LLC, Baltimore, MD, United States, ²TherVoyant, Madison, WI, United States, ³Medical Physics, Madison, Madison, WI, United States, ⁴Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ⁵Psychiatry, University of Wisconsin - Madison, Madison, WI, United States, ⁶Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, ⁷Radiology, University of Wisconsin- Madison, Madison, WI, United States

The hetergeneity of the brain makes designing a desired end drug distribution through pressurized catheters difficult. We present a method to utilize real-time MR monitoring of a co-infused Gd tracer during initial stages of the infusion to derive a real-time 3D estimate of the velocity front. We demonstrate considerable improvement in predicting the actual drug distribution using the MR real-time data in four cases using a large animal surgical model.

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