Abstract #0605

Real-time MRI-guided endovascular model of cerebral ischemia in swine

Dominika Golubczyk¹, Izabela Malysz-Cymborska¹, Lukasz Kalkowski¹, Michal Zawadzki², Piotr Holak³, Joanna Glodek³, Kamila Milewska¹, Marek Bogacki⁴, Mirosław Janowski^5,6,7, Zbigniew Adamiak³, Wojciech Maksymowicz¹, and Piotr Walczak^1,6,7

¹Department of Neurology and Neurosurgery, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland, ²Central Clinical Hospital of Ministry of the Interior and Administration in Warsaw, Warsaw, Poland, ³Department of Surgery and Roentgenology with the Clinic, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland, ⁴Department of Gamete and Embryo Biology, Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Olsztyn, Poland, ⁵NeuroRepair Department, Mossakowski Medical Research Centre Polish Academy of Sciences, Warsaw, Poland, ⁶Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁷Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Animal models of stroke are essential for developing therapies. Rodent models of stroke are widely used but they lack clinical relevance. Endovascular models in large animals are most desired, but till now they were available in expensive and hard-to-access dogs and primates. Swine is preferred model but till now stroke modeling was through surgical craniotomy, a highly invasive procedure inflicting unrelated morbidity. Endovascular modeling was not possible due to vascular rete preventing catheter access to cerebral vessels. We circumvented this obstacle by intra-arterially injecting SPIO-labeled pro-coagulant thrombin under real-time MRI, which was instrumental to fine-tune injection to occlude cerebral arteries.

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