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Abstract #0606

PET-MRI Quantification of 89Zr-Iron Oxide Nanoparticles for Targeted Magnetic Drug Therapy

Caroline D. Jordan1, Misung Han1, Sravani Kondapavulur1,2, Denis Beckford Vera1, Kiel D. Neumann1, Carol Stillson1, Teri Moore1, Roland Krug1, Spencer Behr1, Youngho Seo1, Henry F. VanBrocklin1, Peder E. Z. Larson1, Mark W. Wilson1, Alastair J. Martin1, and Steven W. Hetts1

1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Bioengineering, University of California, Berkeley, Berkeley, CA, United States

One recent application of magnetic nanoparticles is to deploy an endovascular magnetic device to selectively remove magnetically-linked chemotherapy during an intra-arterial treatment procedure. In order to measure the device’s efficacy, 89Zr-iron oxide nanoparticles could be imaged using PET-MR. We measured quantitative susceptibility values (Δχ), R2*, and 89Zr-PET uptake of increasing concentrations of 89Zr-IONP in vitro, and in liver in vivo by acquiring a multi-echo UTE GRE sequence and time-of-flight PET. Phantom evaluations demonstrated linear correlation between Δχ, R2*, and 89Zr-IONP uptake. In vivo, substantial increase was observed after 89Zr-IONP infusion. This approach shows promise tracking the biodistribution of radiolabelled magnetic nanoparticles.

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