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Abstract #0610

A Novel Analysis Strategy for Assessing Liver Lipid Composition with Magnetic Resonance Spectroscopy

Patrick John Bolan1, Malgorzata Marjanska1, Aaron S Kelly2, and Justin R Ryder2

1Radiology, University of Minnesota, Minneapolis, MN, United States, 2Pediatrics, University of Minnesota, Minneapolis, MN, United States

Measuring lipid composition (e.g., saturation levels) with MRS requires analysis of small lipid resonances in addition to the 1.3 ppm methylene peak. This is straightforward in adipose tissue but difficult in the liver due to lower concentration and greater spectral linewidths. In this work we propose a new fitting method that models the full lipid spectrum from 3 parameters and fits a multi-TE array of spectra simultaneously. This approach produces repeatable and physically reasonable estimations of liver fat composition in a wide range of fat factions.

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