Abstract #0611

Gd-EOB-DTPA-enhanced T1ρ Imaging vs. Diffusion Metrics for Assessment Liver Inflammation and Early Stage Fibrosis of Nonalcoholic Steatohepatitis in Rabbits

Xie Yuanliang^1,2, Wang Xiang³, Zhang Hongfeng⁴, Wang Xiaoqi⁵, Jin Chaolin³, and Xu Yikai⁶

¹Radiology, Southern Medical University, Guangzhou, China, ²Radiology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ³Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ⁴Pathology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ⁵Philips Healthcare, Beijing, China, ⁶Southern Medical University, Guangzhou, China

This study is to evaluate applications of T1ρ, T1ρ on hepatobiliary phase (HBP, with Gd-EOB-DTPA enhancement) and IVIM in assessing of early-stage NASH in rabbits model. Results show that T1ρ (HBP) after Gd-EOB-DTPA administration is a more sensitive method for assessment of NAFLD activity, while a combination of T1ρ(HBP) and IVIM showed highest diagnostic value.

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