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Abstract #0612

Assessment of Portal Hypertension with Multi-parametric Hepatic MR Elastography in Mouse Models

Jiahui Li1, Moira B Hilscher2, Kevin J. Glaser1, Douglas A. Simonetto2, Vijay Shah2, Richard L. Ehman1, and Meng Yin1

1Radiology, Mayo Clinic, Rochester, MN, United States, 2Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States

We used multi-parametric hepatic MR Elastography (MRE) in two different mouse models with congestion and cirrhosis-induced portal hypertension, respectively. Spearman correlation was used to analyze the relationships between the MRE-assessed liver stiffness, damping ratio, volumetric strain, stiffness frequency dispersion, and the portal pressure directly measuared in vivo. We found that volumetric strain and damping ratio had negative correlations (ρ=-0.7515, ρ=-0.5528 respectively), while shear stiffness had a positive correlation (ρ=0.6983) with portal pressure. Additionally, damping ratio changes differently in portal hypertension induced by congestion and cirrhosis. In summary, multi-parametric MRE has potential to differentiate and quantify congestion and cirrhosis-induced portal hypertension.

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