Abstract #0621

Reproducibility of cardiac 31P MRS at 7 T

Jane Ellis¹, Ladislav Valkovic^1,2, Lucian A. B. Purvis¹, William T. Clarke^1,3, and Christopher T. Rodgers^1,4

¹OCMR, RDM Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, ²Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, ³Wellcome Centre for Intergrative Neuroimaging, University of Oxford, Oxford, United Kingdom, ⁴Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom

Cardiac PCr/ATP ratios measured by³¹P MRS change in cardiovascular disease giving them value as a biomarker. We scanned 13 healthy volunteers at 7T, assessing their PCr/ATP with 6 ½ min ³¹P CSI scans. These data have better reproducibility than a 30min 3T protocol previously published by our centre. Repeated PCr/ATP measurements from subjects in this study were not significantly (P=0.83) different. Measurements were significantly different (P<0.001) from DCM patient data acquired in a previous 7T study using the same coil and pulse sequence. This data will allow us to plan future 7T³¹P-MRS clinical studies.

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