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Abstract #0621

Reproducibility of cardiac 31P MRS at 7 T

Jane Ellis1, Ladislav Valkovic1,2, Lucian A. B. Purvis1, William T. Clarke1,3, and Christopher T. Rodgers1,4

1OCMR, RDM Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, 2Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, 3Wellcome Centre for Intergrative Neuroimaging, University of Oxford, Oxford, United Kingdom, 4Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom

Cardiac PCr/ATP ratios measured by 31P MRS change in cardiovascular disease giving them value as a biomarker. We scanned 13 healthy volunteers at 7T, assessing their PCr/ATP with 6 ½ min 31P CSI scans. These data have better reproducibility than a 30min 3T protocol previously published by our centre. Repeated PCr/ATP measurements from subjects in this study were not significantly (P=0.83) different. Measurements were significantly different (P<0.001) from DCM patient data acquired in a previous 7T study using the same coil and pulse sequence. This data will allow us to plan future 7T 31P-MRS clinical studies.

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