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Abstract #0624

Dynamic perfusion and T2*-weighted 1H MRI interleaved with multivoxel 31P MRS of exercising human calf at 7T

Fabian Niess1,2, Albrecht Schmid1,3, Georg Bernd Fiedler1,2, Roberta Frass1,2, Wolfgang Bogner2,4, Alfredo Lopez Kolkovsky5, Pierre Carlier5, Ewald Moser1,2, and Martin Meyerspeer1,2

1Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, 2MR Center of Excellence, Medical University of Vienna, Vienna, Austria, 3Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, 4Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 5NMR laboratory, Institute of Myology, Paris, France

To quantify perfusion and high-energy metabolite time courses of exercising gastrocnemius and soleus muscles in one time-resolved acquisition, 1H arterial spin labeling with multislice EPI was interleaved with multivoxel semi-LASER 31P-MRS. Perfusion mapping and T2* weighted MRI yielded reasonable time courses and were less sensitive to motion, compared to single slice acquisitions. Spectroscopic time courses of phosphocreatine, inorganic phosphate and pH with fitted PCr recovery time constants were consistent with literature in both GM and SOL. A significant 31P SNR increase was found when the VOI perceived adiabatic 1H inversion which can be explained by NOE.

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