Abstract #0624

Dynamic perfusion and T2*-weighted 1H MRI interleaved with multivoxel 31P MRS of exercising human calf at 7T

Fabian Niess^1,2, Albrecht Schmid^1,3, Georg Bernd Fiedler^1,2, Roberta Frass^1,2, Wolfgang Bogner^2,4, Alfredo Lopez Kolkovsky⁵, Pierre Carlier⁵, Ewald Moser^1,2, and Martin Meyerspeer^1,2

¹Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, ²MR Center of Excellence, Medical University of Vienna, Vienna, Austria, ³Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, ⁴Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ⁵NMR laboratory, Institute of Myology, Paris, France

To quantify perfusion and high-energy metabolite time courses of exercising gastrocnemius and soleus muscles in one time-resolved acquisition, ¹H arterial spin labeling with multislice EPI was interleaved with multivoxel semi-LASER ³¹P-MRS. Perfusion mapping and T₂* weighted MRI yielded reasonable time courses and were less sensitive to motion, compared to single slice acquisitions. Spectroscopic time courses of phosphocreatine, inorganic phosphate and pH with fitted PCr recovery time constants were consistent with literature in both GM and SOL. A significant ³¹P SNR increase was found when the VOI perceived adiabatic ¹H inversion which can be explained by NOE.

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